Rimonabant drug mechanism of action and working of Remonabant

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How does Rimonabant work?
Rimonabant also known as Accomplia is believed to be the wonder medication launched by the world forerunner pharmaceutical group called Sanofi-Aventis, for the treatment of obesity and smoking cessation – the two major causes of deaths as compared to any other disorders in the world nowadays. The theory linked with Rimonabant and weight loss rotates around the endocannabinoid system-EC that gets over activated because of overeating or tobacco dependency.

Rimonabant is believed to act by suppressing the craving or appetite which ultimately leads to weight loss. The drug is also considered to suppress smoking desire for the regular smokers which helps them to quit smoking without weight gain. Technically Rimonabant works by blocking the passage of several chemicals in the brain area that makes us feel hunger. The medication binds to specific chemical receptors in the brain called endocannabinoid receptors. Such binding makes the receptors insensitive to activation by chemical called cannabinoid. This chemical is recognized to excite hunger and food cravings.

It is also reported that marijuana excites cannabinoid receptors leaving the users feel less hungry or suppress appetite leading you to eat less and ultimately lose weight. During the specific clinical trials on persons who took Rimonabant reported weight loss of up to 20 pounds during the year along with the remarkable drop in their waistline area. The major weight loss was however reported during the first year treatment regimen.

For smokers, Rimonabant may help them restricting their smoking desires. Based on one typical study, the medication just doubled the chances of smoking cessation perhaps for the shorter phase for the regular smoker. Rimonabant is also effectively helping to diminish the fat levels in the blood.


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